by Mapping Human Monoclonal IgE Epitopes on the Main Mud Mite Allergen Der p 2
IgE Abs drive the signs of allergic illness upon cross-linking allergens on mast cells or basophils. If the IgE binding websites on the allergens may very well be recognized, it could be helpful for creating new types of immunotherapy. Nonetheless, direct information of the human IgE (hIgE) epitopes is proscribed due to the very low frequency of IgE-producing B cells in blood.
A brand new hybridoma know-how utilizing human B cells from home mud mite-allergic sufferers was used to determine 4 Der p 2-specific hIgE mAbs. Their relative binding websites have been assessed and in contrast by immunoassays with three beforehand studied murine IgG mAbs. Immunoassays confirmed that the popularity of Der p 2 by the primary three hIgE was inhibited by a single murine IgG, however the fourth hIgE acknowledged a distinct epitope from all the opposite mAbs.
The useful potential of the hIgE that bind totally different epitopes to cross-link Der p 2 was demonstrated in a mouse mannequin of passive systemic anaphylaxis. Nuclear magnetic resonance analyses of Der p 2 in complicated with IgG and IgE Abs have been used to determine particular residues within the epitopes.
To our information, the mixture of immunoassays to differentiate overlapping epitopes and nuclear magnetic resonance analyses to determine particular residues concerned in Ab binding supplied the primary epitope mapping of hIgE mAbs to an allergen. The applied sciences developed on this examine shall be helpful in high-resolution mapping of human epitopes on different Ags and the design of improved therapeutics.
Human Lactate Dehydrogenase A (LDHA) ELISA Kit |
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| RDR-LDHA-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 868.8 |
Rat Lactate Dehydrogenase A (LDHA) ELISA Kit |
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| RDR-LDHA-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 669.6 |
Rat Lactate Dehydrogenase A (LDHA) ELISA Kit |
|||
| RDR-LDHA-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 931.2 |
Human Lactate Dehydrogenase A (LDHA) ELISA Kit |
|||
| RD-LDHA-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Lactate Dehydrogenase A (LDHA) ELISA Kit |
|||
| RD-LDHA-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Rat Lactate Dehydrogenase A (LDHA) ELISA Kit |
|||
| RD-LDHA-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Lactate Dehydrogenase A (LDHA) ELISA Kit |
|||
| RD-LDHA-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
LDHA antibody |
|||
| 70R-3736 | Fitzgerald | 50 ug | EUR 560.4 |
|
Description: Rabbit polyclonal LDHA antibody raised against the N terminal of LDHA |
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LDHA antibody |
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| 70R-3851 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Rabbit polyclonal LDHA antibody raised against the middle region of LDHA |
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LDHA antibody |
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| 70R-18236 | Fitzgerald | 50 ul | EUR 522 |
|
Description: Rabbit polyclonal LDHA antibody |
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LDHA antibody |
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| 70R-15197 | Fitzgerald | 100 ug | EUR 392.4 |
|
Description: Rabbit polyclonal LDHA antibody |
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LDHA Antibody |
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| 32182-100ul | SAB | 100ul | EUR 302.4 |
LDHA Antibody |
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| 48492-100ul | SAB | 100ul | EUR 399.6 |
LDHA Antibody |
|||
| 48492-50ul | SAB | 50ul | EUR 286.8 |
LDHA antibody |
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| 10R-10600 | Fitzgerald | 100 ug | EUR 418.8 |
|
Description: Mouse monoclonal LDHA antibody |
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LDHA antibody |
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| 10R-1177 | Fitzgerald | 100 ul | EUR 379.2 |
|
Description: Mouse monoclonal LDHA antibody |
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LDHA antibody |
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| 10R-8620 | Fitzgerald | 100 ul | EUR 471.6 |
|
Description: Mouse monoclonal LDHA antibody |
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LDHA antibody |
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| 10R-8621 | Fitzgerald | 100 ul | EUR 471.6 |
|
Description: Mouse monoclonal LDHA antibody |
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LDHA antibody |
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| 10R-4599 | Fitzgerald | 100 ul | EUR 829.2 |
|
Description: Mouse monoclonal LDHA antibody |
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LDHA Antibody |
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| ABD6280 | Lifescience Market | 100 ug | EUR 525.6 |
LDHA Antibody |
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| AF7672 | Affbiotech | 200ul | EUR 540 |
LDHA Antibody |
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| AF7673 | Affbiotech | 200ul | EUR 540 |
LDHA Antibody |
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| 1-CSB-PA00045A0Rb | Cusabio |
|
|
|
Description: A polyclonal antibody against LDHA. Recognizes LDHA from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
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LDHA Antibody |
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| DF6280 | Affbiotech | 200ul | EUR 420 |
LDHA Antibody |
|||
| 1-CSB-PA012832GA01HU | Cusabio |
|
|
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Description: A polyclonal antibody against LDHA. Recognizes LDHA from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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LDHA Antibody |
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| R35857-100UG | NSJ Bioreagents | 100 ug | EUR 399 |
LDHA Antibody |
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| F51766-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
LDHA Antibody |
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| F51766-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
LDHA Antibody |
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| F43050-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
LDHA Antibody |
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| F43050-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
LDHA antibody (HRP) |
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| 60R-1430 | Fitzgerald | 100 ug | EUR 392.4 |
|
Description: Rabbit polyclonal LDHA antibody (HRP) |
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LDHA antibody (FITC) |
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| 60R-1431 | Fitzgerald | 100 ug | EUR 392.4 |
|
Description: Rabbit polyclonal LDHA antibody (FITC) |
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LDHA antibody (biotin) |
|||
| 60R-1432 | Fitzgerald | 100 ug | EUR 392.4 |
|
Description: Rabbit polyclonal LDHA antibody (biotin) |
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Human LDHA Antibody |
|||
| 33156-05111 | AssayPro | 150 ug | EUR 313.2 |
LDHA Polyclonal Antibody |
|||
| ABP59104-003ml | Abbkine | 0.03ml | EUR 189.6 |
|
Description: A polyclonal antibody for detection of LDHA from Human, Mouse, Rat. This LDHA antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human LDHA protein |
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LDHA Polyclonal Antibody |
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| ABP59104-01ml | Abbkine | 0.1ml | EUR 346.8 |
|
Description: A polyclonal antibody for detection of LDHA from Human, Mouse, Rat. This LDHA antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human LDHA protein |
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LDHA Polyclonal Antibody |
|||
| ABP59104-02ml | Abbkine | 0.2ml | EUR 496.8 |
|
Description: A polyclonal antibody for detection of LDHA from Human, Mouse, Rat. This LDHA antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human LDHA protein |
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LDHA-Specific Antibody |
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| abx234737-100ug | Abbexa | 100 ug | EUR 610.8 |
LDHA Conjugated Antibody |
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| C32182 | SAB | 100ul | EUR 476.4 |
LDHA Polyclonal Antibody |
|||
| ES11979-100ul | ELK Biotech | 100ul | EUR 334.8 |
|
Description: A Rabbit Polyclonal antibody against LDHA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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LDHA Polyclonal Antibody |
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| ES11979-50ul | ELK Biotech | 50ul | EUR 248.4 |
|
Description: A Rabbit Polyclonal antibody against LDHA from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Anti-LDHA antibody |
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| PAab04735 | Lifescience Market | 100 ug | EUR 426 |
anti- LDHA antibody |
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| FNab04735 | FN Test | 100µg | EUR 606.3 |
|
Description: Antibody raised against LDHA |
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Anti-LDHA Antibody |
|||
| PB10075 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-LDHA antibody |
|||
| STJ110987 | St John's Laboratory | 100 µl | EUR 332.4 |
|
Description: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. |
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Anti-LDHA antibody |
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| STJ118834 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-LDHA antibody |
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| STJ73383 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-LDHA antibody |
|||
| STJ24386 | St John's Laboratory | 100 µl | EUR 332.4 |
|
Description: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. |
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Anti-LDHA antibody |
|||
| STJ193137 | St John's Laboratory | 200 µl | EUR 236.4 |
|
Description: Unconjugated Rabbit polyclonal to LDHA |
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LDHA Polyclonal Antibody |
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| A52408-020 | EpiGentek | 20 ul | Ask for price |
LDHA Polyclonal Antibody |
|||
| A52408-050 | EpiGentek | 50 ul | Ask for price |
LDHA Polyclonal Antibody |
|||
| A52408-100 | EpiGentek | 100 ul | EUR 423.5 |
LDHA Polyclonal Antibody |
|||
| A70919-050 | EpiGentek | 50 ul | EUR 302.5 |
LDHA Polyclonal Antibody |
|||
| A70919-100 | EpiGentek | 100 ul | EUR 423.5 |
LDHA Polyclonal Antibody |
|||
| A70920-050 | EpiGentek | 50 ul | EUR 302.5 |
LDHA Polyclonal Antibody |
|||
| A70920-100 | EpiGentek | 100 ul | EUR 423.5 |
LDHA Polyclonal Antibody |
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| A52408 | EpiGentek |
|
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LDHA Polyclonal Antibody |
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| A70919 | EpiGentek |
|
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LDHA Polyclonal Antibody |
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| A70920 | EpiGentek |
|
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LDHA Antibody (CT) |
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| 6735-100 | Biovision | each | EUR 379.2 |
LDHA Antibody (Center) |
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| 6736-100 | Biovision | each | EUR 379.2 |
Ldha/ Rat Ldha ELISA Kit |
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| ELI-07039r | Lifescience Market | 96 Tests | EUR 1063.2 |
LDHA Peptide |
|||
| 43-515P | ProSci | 0.1 mg | EUR 405.6 |
LDHA protein |
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| 30R-3121 | Fitzgerald | 50 ug | EUR 308.4 |
|
Description: Purified recombinant LDHA protein |
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LDHA protein |
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| 30R-3158 | Fitzgerald | 50 ug | EUR 308.4 |
|
Description: Purified recombinant LDHA protein |
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LDHA siRNA |
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| 20-abx902947 | Abbexa |
|
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LDHA siRNA |
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| 20-abx922385 | Abbexa |
|
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LDHA siRNA |
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| 20-abx922386 | Abbexa |
|
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anti-LDHA |
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| YF-PA12933 | Abfrontier | 50 ug | EUR 435.6 |
|
Description: Mouse polyclonal to LDHA |
|||
anti-LDHA |
|||
| YF-PA12934 | Abfrontier | 100 ul | EUR 483.6 |
|
Description: Rabbit polyclonal to LDHA |
|||
anti-LDHA |
|||
| YF-PA12935 | Abfrontier | 100 ug | EUR 483.6 |
|
Description: Rabbit polyclonal to LDHA |
|||
LDHA (Phospho-Tyr10) Antibody |
|||
| 13035-100ul | SAB | 100ul | EUR 302.4 |
LDHA (Phospho-Tyr10) Antibody |
|||
| 13035-50ul | SAB | 50ul | EUR 224.4 |
LDHA (Phospho-Tyr239) Antibody |
|||
| 13036-100ul | SAB | 100ul | EUR 302.4 |
LDHA (Phospho-Tyr239) Antibody |
|||
| 13036-50ul | SAB | 50ul | EUR 224.4 |
E. Coli ldhA Antibody |
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| 32898-05111 | AssayPro | 150 ug | EUR 313.2 |
Phospho- LDHA (Tyr10) Antibody |
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| ABF3640 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho-LDHA (Tyr10) Antibody |
|||
| AF7172 | Affbiotech | 200ul | EUR 540 |
Phospho-LDHA (Tyr239) Antibody |
|||
| AF7173 | Affbiotech | 200ul | EUR 540 |
Polyclonal LDHA Antibody (Center) |
|||
| APR08178G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDHA (Center). This antibody is tested and proven to work in the following applications: |
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Polyclonal LDHA Antibody (Center) |
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| APR08179G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDHA (Center). This antibody is tested and proven to work in the following applications: |
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Polyclonal LDHA Antibody (Center) |
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| APR08180G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDHA (Center). This antibody is tested and proven to work in the following applications: |
|||
Polyclonal LDHA Antibody (CT) |
|||
| APR08201G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDHA (CT). This antibody is tested and proven to work in the following applications: |
|||
LDHA Antibody, HRP conjugated |
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| 1-CSB-PA00045B0Rb | Cusabio |
|
|
|
Description: A polyclonal antibody against LDHA. Recognizes LDHA from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
|||
LDHA Antibody, FITC conjugated |
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| 1-CSB-PA00045C0Rb | Cusabio |
|
|
|
Description: A polyclonal antibody against LDHA. Recognizes LDHA from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
|||
LDHA Antibody, Biotin conjugated |
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| 1-CSB-PA00045D0Rb | Cusabio |
|
|
|
Description: A polyclonal antibody against LDHA. Recognizes LDHA from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
|||
Anti-LDHA-Specific antibody |
|||
| PAab04737 | Lifescience Market | 100 ug | EUR 463.2 |
anti- LDHA-Specific antibody |
|||
| FNab04737 | FN Test | 100µg | EUR 658.5 |
|
Description: Antibody raised against LDHA-Specific |
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Human LDHA Antibody (Biotin Conjugate) |
|||
| 33156-05121 | AssayPro | 150 ug | EUR 442.8 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| 20-abx137242 | Abbexa |
|
|
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| 20-abx102382 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
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| 20-abx102383 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
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| 20-abx102384 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
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| 20-abx001060 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
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| 20-abx109970 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
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| 20-abx129926 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
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| 20-abx126960 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
|||
| 20-abx113425 | Abbexa |
|
|
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx018062-100ug | Abbexa | 100 ug | EUR 460.8 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| 20-abx018063 | Abbexa |
|
|
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx034405-400ul | Abbexa | 400 ul | EUR 627.6 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx034405-80l | Abbexa | 80 µl | EUR 343.2 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx027454-400ul | Abbexa | 400 ul | EUR 627.6 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx027454-80l | Abbexa | 80 µl | EUR 343.2 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| 20-abx225267 | Abbexa |
|
|
Lactate Dehydrogenase A (ldhA) Antibody |
|||
| 20-abx300126 | Abbexa |
|
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Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx432921-200ul | Abbexa | 200 ul | EUR 460.8 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| abx234735-100ug | Abbexa | 100 ug | EUR 560.4 |
Lactate Dehydrogenase A (LDHA) Antibody |
|||
| 20-abx173288 | Abbexa |
|
|
Polyclonal LDHA Antibody (C-Term) |
|||
| APR08175G | Leading Biology | 0.1 mg | EUR 580.8 |
|
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human LDHA (C-Term). This antibody is tested and proven to work in the following applications: |
|||
Polyclonal LDHA Antibody (C-term) |
|||
| APR08176G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDHA (C-term). This antibody is tested and proven to work in the following applications: |
|||
Polyclonal LDHA Antibody (C-term) |
|||
| APR08177G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDHA (C-term). This antibody is tested and proven to work in the following applications: |
|||
LDHA (Phospho-Tyr10) Conjugated Antibody |
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| C13035 | SAB | 100ul | EUR 476.4 |
LDHA (Phospho-Tyr239) Conjugated Antibody |
|||
| C13036 | SAB | 100ul | EUR 476.4 |
Anti-Phospho-LDHA-Y10 antibody |
|||
| STJ11101026 | St John's Laboratory | 100 µl | EUR 471.6 |
|
Description: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. |
|||
LDHA Polyclonal Antibody, Biotin Conjugated |
|||
| A52405-050 | EpiGentek | 50 ul | EUR 302.5 |
LDHA Polyclonal Antibody, Biotin Conjugated |
|||
| A52405-100 | EpiGentek | 100 ul | EUR 423.5 |
LDHA Polyclonal Antibody, FITC Conjugated |
|||
| A52406-050 | EpiGentek | 50 ul | EUR 302.5 |
LDHA Polyclonal Antibody, FITC Conjugated |
|||
| A52406-100 | EpiGentek | 100 ul | EUR 423.5 |
LDHA Polyclonal Antibody, HRP Conjugated |
|||
| A52407-050 | EpiGentek | 50 ul | EUR 302.5 |
LDHA Polyclonal Antibody, HRP Conjugated |
|||
| A52407-100 | EpiGentek | 100 ul | EUR 423.5 |
LDHA Polyclonal Antibody, Biotin Conjugated |
|||
| A52405 | EpiGentek |
|
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LDHA Polyclonal Antibody, FITC Conjugated |
|||
| A52406 | EpiGentek |
|
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LDHA Polyclonal Antibody, HRP Conjugated |
|||
| A52407 | EpiGentek |
|
|
LDHA Antibody / Lactate dehydrogenase A |
|||
| R32543 | NSJ Bioreagents | 100 ug | EUR 419 |
LDHA Antibody / Lactate dehydrogenase A |
|||
| RQ4831 | NSJ Bioreagents | 100ul | EUR 419 |
LDHA Rabbit pAb |
|||
| A0543-100ul | Abclonal | 100 ul | EUR 369.6 |
LDHA Rabbit pAb |
|||
| A0543-200ul | Abclonal | 200 ul | EUR 550.8 |
LDHA Rabbit pAb |
|||
| A0543-20ul | Abclonal | 20 ul | Ask for price |
LDHA Rabbit pAb |
|||
| A0543-50ul | Abclonal | 50 ul | Ask for price |
LDHA Rabbit mAb |
|||
| A0861-100ul | Abclonal | 100 ul | EUR 492 |
LDHA Rabbit mAb |
|||
| A0861-200ul | Abclonal | 200 ul | EUR 685.2 |
LDHA Rabbit mAb |
|||
| A0861-20ul | Abclonal | 20 ul | EUR 265.2 |
LDHA Rabbit mAb |
|||
| A0861-50ul | Abclonal | 50 ul | EUR 344.4 |
LDHA Rabbit pAb |
|||
| A1146-100ul | Abclonal | 100 ul | EUR 369.6 |
LDHA Rabbit pAb |
|||
| A1146-200ul | Abclonal | 200 ul | EUR 550.8 |
LDHA Rabbit pAb |
|||
| A1146-20ul | Abclonal | 20 ul | EUR 219.6 |
LDHA Rabbit pAb |
|||
| A1146-50ul | Abclonal | 50 ul | EUR 267.6 |
LDHA Blocking Peptide |
|||
| 33R-1565 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDHA antibody, catalog no. 70R-3736 |
|||
LDHA Blocking Peptide |
|||
| 33R-7206 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDHA antibody, catalog no. 70R-3851 |
|||
LDHA Rabbit pAb |
|||
| A16394-100ul | Abclonal | 100 ul | EUR 369.6 |
LDHA Rabbit pAb |
|||
| A16394-200ul | Abclonal | 200 ul | EUR 550.8 |
LDHA Rabbit pAb |
|||
| A16394-20ul | Abclonal | 20 ul | EUR 219.6 |
LDHA Rabbit pAb |
|||
| A16394-50ul | Abclonal | 50 ul | EUR 267.6 |
Plant-Produced Monoclonal Antibody as Immunotherapy for Most cancers
Plant-based merchandise have expanded to embody most cancers immunotherapy, which has made nice strides over latest years. Crops are thought-about cheap and facile manufacturing platforms for recombinant monoclonal antibody (mAb) because of the newest developments and diversification of transgenic methods.
Present human biologics, together with these primarily based on mAbs produced by fermentation applied sciences utilizing primarily mammalian cell cultures, have been changed by plant-produced mAbs, that are value efficient, extra scalable, speedy, versatile, and safer. Furthermore, the usage of animals for antibody manufacturing is all the time a query of moral unambiguity, and the suitability of animal fashions for predicting the immunogenicity of therapeutic mAbs in people and transposition of the immunogenic potential of therapeutic antibodies in animals to the human scenario has no scientific rationale.
Fairly a couple of plant-based mAbs are permitted for the remedy of most cancers, starting from tumors to hematological malignancies. This assessment focuses on the cutting-edge approaches for utilizing plant-derived mAbs to suppress or forestall cancers. It additionally discusses the avenues taken to forestall an infection by oncogenic viruses, stable tumors, lymphomas, and different cancerous circumstances utilizing mAbs. The assessment emphasizes the usage of a plant-derived monoclonal antibody as a premier platform to fight most cancers.
A price evaluation examine of the implementation of fixed-dosing of monoclonal antibodies within the Netherlands Most cancers Institute
Background There’s a robust rationale for fixed-dosing of monoclonal antibodies in oncology. Though fixed-dosing of not too long ago launched monoclonal antibodies is nicely accepted, the rationale can also be relevant for different monoclonal antibodies that have already got been used for years, however are nonetheless body-size-based dosed in many hospitals.
Within the Netherlands Most cancers Institute, Antoni van Leeuwenhoek (NKI-AVL), fixed-dosing has been applied now for all monoclonal antibodies and, subsequently, this web site provides a great alternative for a value evaluation examine. Goal To research the monetary influence of switching to fixed-dosing within the NKI-AVL. Setting The NKI-AVL. Technique Info on the preparations of monoclonal antibodies was collected from August 2017 to February 2020.
We in contrast the variety of vials wanted throughout preparation for fixed-dosing and body-size -based dosing methods. The financial influence was calculated for two situations: situation 1 assumed clustering of all preparations per day and situation 2 assumed no clustering of preparations. Most important consequence measure Variety of saved vials and the correlating financial savings in well being care prices.
Outcomes The implementation of fixed-dosing resulted in a considerable discount in vials used for nearly all monoclonal antibodies. The financial financial savings have been calculated to be €0,eight and €3,1 million per 12 months for situation 1 and a couple of, respectively. Conclusion Mounted-dosing resulted in substantial financial savings in well being care prices.
Rat Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Rat Immunoglobulin G1 Lambda Myeloma (IgG1 Lambda Myeloma) Protein |
|||
| abx670334-1mg | Abbexa | 1 mg | EUR 627.6 |
Kappa; Clone L1C1 (Concentrate) |
|||
| A00113-C | ScyTek Laboratories | 1 ml | EUR 524.4 |
Kappa; Clone L1C1 (Concentrate) |
|||
| A00113-C.1 | ScyTek Laboratories | 0.1 ml | EUR 165.6 |
Rat Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative |
|||
| 4270-30-IGA | Alpha Diagnostics | 1 Kit | EUR 1074 |
RecombiVirus Rat Epizootic diarrhea of infant mice (EDIM)/rotavirus IgA ELISA Kit, 2x96 tests |
|||
| AE-300415-IgA | Alpha Diagnostics | 1 Kit | EUR 1512 |
Bovine Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-b-48T | DL Develop | 48T | EUR 656.4 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Immunoglobulin A (IgA) in samples from serum, plasma, saliva or other biological fluids. |
|||
Bovine Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-b-96T | DL Develop | 96T | EUR 858 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Immunoglobulin A (IgA) in samples from serum, plasma, saliva or other biological fluids. |
|||
Chicken Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-Ch-48T | DL Develop | 48T | EUR 609.6 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids. |
|||
Chicken Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-Ch-96T | DL Develop | 96T | EUR 793.2 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids. |
|||
Human Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-Hu-48T | DL Develop | 48T | EUR 529.2 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin A (IgA) in samples from serum, plasma, saliva or other biological fluids. |
|||
Human Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-Hu-96T | DL Develop | 96T | EUR 684 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin A (IgA) in samples from serum, plasma, saliva or other biological fluids. |
|||
Mouse Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-Mu-48T | DL Develop | 48T | EUR 586.8 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids. |
|||
Mouse Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-Mu-96T | DL Develop | 96T | EUR 762 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids. |
|||
Porcine Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-p-48T | DL Develop | 48T | EUR 656.4 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids. |
|||
Porcine Immunoglobulin A (IgA) ELISA Kit |
|||
| DLR-IgA-p-96T | DL Develop | 96T | EUR 858 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Immunoglobulin A (IgA) in samples from serum, plasma or other biological fluids. |
|||
Bovine Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-b-48Tests | Reddot Biotech | 48 Tests | EUR 696 |
Bovine Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-b-96Tests | Reddot Biotech | 96 Tests | EUR 968.4 |
Chicken Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-Ch-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Chicken Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-Ch-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Human Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 546 |
Human Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 754.8 |
Mouse Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Mouse Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Porcine Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-p-48Tests | Reddot Biotech | 48 Tests | EUR 696 |
Porcine Immunoglobulin A (IgA) ELISA Kit |
|||
| RDR-IgA-p-96Tests | Reddot Biotech | 96 Tests | EUR 968.4 |
Bovine Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-b-48Tests | Reddot Biotech | 48 Tests | EUR 666 |
Bovine Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-b-96Tests | Reddot Biotech | 96 Tests | EUR 925.2 |
Mouse Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 586.8 |
Mouse Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 812.4 |
Porcine Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-p-48Tests | Reddot Biotech | 48 Tests | EUR 666 |
Porcine Immunoglobulin A (IgA) ELISA Kit |
|||
| RD-IgA-p-96Tests | Reddot Biotech | 96 Tests | EUR 925.2 |
Human IgE (myeloma, kappa), purified (isotype control, >95%, low endotoxin, azide free) |
|||
| 20007-3-LE-50 | Alpha Diagnostics | 100 ug | EUR 489.6 |
Human IgE Myeloma, Lambda |
|||
| 31R-AI032 | Fitzgerald | 200 ug | EUR 930 |
|
Description: Purified Human IgE Myeloma, Lambda |
|||
Human IgG1, Myeloma Plasma |
|||
| 20007-G1-1 | Alpha Diagnostics | 1 mg | EUR 242.4 |
Human IgG2, Myeloma Plasma |
|||
| 20007-G2-1 | Alpha Diagnostics | 1 mg | EUR 242.4 |
Human IgG3, Myeloma Plasma |
|||
| 20007-G3-1 | Alpha Diagnostics | 1 mg | EUR 489.6 |
Human IgG4, Myeloma Plasma |
|||
| 20007-G4-500 | Alpha Diagnostics | 500 ug | EUR 270 |
Human Myeloma IgE Protein |
|||
| abx061000-100ug | Abbexa | 100 ug | EUR 1387.2 |
Human Myeloma IgM Protein |
|||
| abx061005-5mg | Abbexa | 5 mg | EUR 393.6 |
Human Myeloma IgM Protein |
|||
| abx061006-2mg | Abbexa | 2 mg | EUR 644.4 |
Myeloma Overexpressed (MYEOV) Antibody |
|||
| 20-abx113918 | Abbexa |
|
|
Myeloma Overexpressed (MYEOV) Antibody |
|||
| abx235466-100ug | Abbexa | 100 ug | EUR 661.2 |
IL6 antibody |
|||
| 70-IR22 | Fitzgerald | 50 ug | EUR 357.6 |
|
Description: Affinity purified Rabbit polyclonal IL6 antibody |
|||
Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 |
|||
| MASF-5A-Clone-10E11 | Immunology Consultants Laboratory | 1 mg | EUR 667 |
|
Description: Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
|||
Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 |
|||
| MASF-5A-Clone-10G5 | Immunology Consultants Laboratory | 1 mg | EUR 667 |
|
Description: Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
|||
Kappa; Clone L1C1 (Ready-To-Use) |
|||
| A00113-0002 | ScyTek Laboratories | 2 ml | EUR 82.8 |
Kappa; Clone L1C1 (Ready-To-Use) |
|||
| A00113-0007 | ScyTek Laboratories | 7 ml | EUR 114 |
Kappa; Clone L1C1 (Ready-To-Use) |
|||
| A00113-0025 | ScyTek Laboratories | 25 ml | EUR 225.6 |
Kappa Light Chain; Clone KLC264 (Concentrate) |
|||
| A00156-C | ScyTek Laboratories | 1 ml | EUR 596.4 |
Kappa Light Chain; Clone KLC264 (Concentrate) |
|||
| A00156-C.1 | ScyTek Laboratories | 0.1 ml | EUR 165.6 |
Human IgE-Biotin (myeloma, kappa), purified (isotype control, >95%, low endotoxin, azide free) |
|||
| 20007-3-LE-BTN | Alpha Diagnostics | 100 ul | EUR 489.6 |
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 |
|||
| MALV-30A-Clone-3B11 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
|
Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
|||
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 |
|||
| MALV-30A-Clone-5A4 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
|
Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
|||
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 |
|||
| MALV-30A-Clone-6C2 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
|
Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
|||
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 |
|||
| MALV-30A-Clone-6D7 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
|
Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
|||
Human Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative |
|||
| 4200-30-IGA | Alpha Diagnostics | 1 Kit | EUR 1074 |
Mouse Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative |
|||
| 4210-30-IGA | Alpha Diagnostics | 1 Kit | EUR 1074 |
Monkey Anti-Hepatitis B Surface Antigen (anti-HBsAg) IgA ELISA kit, 96 tests, quantitative |
|||
| 4250-30-IGA | Alpha Diagnostics | 1 Kit | EUR 1220.4 |
Recombivirus? Human Anti-Zika Virus (ZIKV) NS1 protein IgA ELISA kit, 96 tests, Quantitative |
|||
| RV-403300-IgA | Alpha Diagnostics | 1 Kit | EUR 1365.6 |
IgA/ Rat IgA ELISA Kit |
|||
| ELA-E0546r | Lifescience Market | 96 Tests | EUR 1063.2 |
Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
|||
| RAT-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
Mouse Anti-Meningococcal A/C/W/Y Oligosaccharides IgA (Combo) ELISA Kit, 96 tests, Quantitative |
|||
| 600-888-IGA | Alpha Diagnostics | 1 Kit | EUR 1220.4 |
Human Anti-Meningococcal Group A/C/W/Y Oligosaccharides IgA (Combo) ELISA Kit, 96 tests, Quantitative |
|||
| 600-883-IGA | Alpha Diagnostics | 1 Kit | EUR 1220.4 |
Human IgG1 Fab fragment (myeloma) |
|||
| 20007-G1-Fab | Alpha Diagnostics | 100 ug | EUR 270 |
Human Myeloma IgA1 lambda Protein |
|||
| abx060998-5mg | Abbexa | 5 mg | EUR 644.4 |
Human Myeloma IgE lambda Protein |
|||
| abx061003-1mg | Abbexa | 1 mg | EUR 4869.6 |
Myeloma Overexpressed 2 (MYEOV2) Antibody |
|||
| abx235467-100ug | Abbexa | 100 ug | EUR 661.2 |
Monoclonal Kappa light chain Antibody, Clone: HP6053 |
|||
| AMM02380G | Leading Biology | 0.1ml | EUR 580.8 |
|
Description: A Monoclonal antibody against Human Kappa light chain. The antibodies are raised in Mouse and are from clone HP6053. This antibody is applicable in WB and IHC-P, E |
|||
Rat Immunoglobulin A (IgA) ELISA Kit |
|||
| SEA546Ra-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5552.14 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Immunoglobulin A (IgA) in serum, plasma and other biological fluids. |
|||
Rat Immunoglobulin A (IgA) ELISA Kit |
|||
| SEA546Ra-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 562.42 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Immunoglobulin A (IgA) in serum, plasma and other biological fluids. |
|||
Rat Immunoglobulin A (IgA) ELISA Kit |
|||
| SEA546Ra-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 752.02 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Immunoglobulin A (IgA) in serum, plasma and other biological fluids. |
|||
Rat Immunoglobulin A (IgA) ELISA Kit |
|||
| SEA546Ra-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3024.07 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Immunoglobulin A (IgA) in serum, plasma and other biological fluids. |
|||
Rat Immunoglobulin A (IgA) ELISA Kit |
|||
| 4-SEA546Ra | Cloud-Clone |
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Immunoglobulin A (IgA) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
|||
Rat Infectiousmononucleosis IgA(IM-IgA)ELISA Kit |
|||
| QY-E10629 | Qayee Biotechnology | 96T | EUR 433.2 |
Mouse Anti-Ovalbumin IgA Monoclonal Antibody, Clone 2G12E12 |
|||
| 7090 | Chondrex | 1 mg/ml x 0.1 ml | EUR 406.26 |
|
Description: Mouse Anti-Ovalbumin IgA Monoclonal Antibody |
|||
Anti-CD79a Antibody Clone IGA/764, Unconjugated-100ug |
|||
| 973-MSM4-P1 | EnQuireBio | 100ug | EUR 513.6 |
Anti-CD79a Antibody Clone IGA/515, Unconjugated-100ug |
|||
| 973-MSM5-P1 | EnQuireBio | 100ug | EUR 513.6 |
Anti-CD79a Antibody Clone IGA/1406, Unconjugated-20ug |
|||
| 973-MSM6-P0 | EnQuireBio | 20ug | EUR 279.6 |
Anti-CD79a Antibody Clone IGA/1406, Unconjugated-100ug |
|||
| 973-MSM6-P1 | EnQuireBio | 100ug | EUR 513.6 |
Anti-CD79a Antibody Clone IGA/1688R, Unconjugated-20ug |
|||
| 973-RBM8-P0 | EnQuireBio | 20ug | EUR 279.6 |
Anti-CD79a Antibody Clone IGA/1688R, Unconjugated-100ug |
|||
| 973-RBM8-P1 | EnQuireBio | 100ug | EUR 513.6 |
Mouse Anti-HDM IgA Monoclonal Antibody, Clone G4H9G12 |
|||
| 7132 | Chondrex | 1 mg/ml x 0.1 ml | EUR 406.26 |
|
Description: Mouse Anti-HDM IgA Monoclonal Antibody |
|||
Monoclonal IgA Secretory Component / ECM1 Antibody, Clone: SC05 |
|||
| AMM00642G | Leading Biology | 7 ml | EUR 580.8 |
|
Description: A Monoclonal antibody against Human IgA Secretory Component / ECM1. The antibodies are raised in Mouse and are from clone SC05. This antibody is applicable in IHC, IF, FC |
|||
Monoclonal IgA Secretory Component / ECM1 Antibody, Clone: SPM217 |
|||
| AMM00643G | Leading Biology | 7 ml | EUR 580.8 |
|
Description: A Monoclonal antibody against Human IgA Secretory Component / ECM1. The antibodies are raised in Mouse and are from clone SPM217. This antibody is applicable in IHC, IF, FC |
|||
Anti-Human IgA Rabbit Monoclonal Antibody, Clone#RM128 |
|||
| M07514-1 | BosterBio | 100ug | EUR 450 |
|
Description: Anti-Human IgA Rabbit Monoclonal Antibody, Clone#RM128 tested in ICC, IHC, FC, ELISA, reactive to Human |
|||
CD79a (B-Cell Marker); Clone IGA/764 (Concentrate) |
|||
| RA0072-C.1 | ScyTek Laboratories | 0.1 ml | EUR 150 |
CD79a (B-Cell Marker); Clone IGA/764 (Concentrate) |
|||
| RA0072-C.5 | ScyTek Laboratories | 0.5 ml | EUR 360 |
CD79a (B-Cell Marker); Clone IGA/515 (Concentrate) |
|||
| RA0073-C.1 | ScyTek Laboratories | 0.1 ml | EUR 150 |
CD79a (B-Cell Marker); Clone IGA/515 (Concentrate) |
|||
| RA0073-C.5 | ScyTek Laboratories | 0.5 ml | EUR 360 |
Kappa, Light Chain; Clone KLC264 (Ready-To-Use) |
|||
| A00156-0002 | ScyTek Laboratories | 2 ml | EUR 123.6 |
Kappa, Light Chain; Clone KLC264 (Ready-To-Use) |
|||
| A00156-0007 | ScyTek Laboratories | 7 ml | EUR 217.2 |
Kappa, Light Chain; Clone KLC264 (Ready-To-Use) |
|||
| A00156-0025 | ScyTek Laboratories | 25 ml | EUR 532.8 |
Monoclonal NF-kappa-B p65 Antibody, Clone: EP2161Y |
|||
| AMM04372G | Leading Biology | 0.1ml | EUR 633.6 |
|
Description: A Monoclonal antibody against Human NF-kappa-B p65. The antibodies are raised in Rabbit and are from clone EP2161Y. This antibody is applicable in WB |
|||
Mouse Anti-Human Kappa monoclonal antibody, clone JID721 |
|||
| CABT-L3016-100uL500uL | Creative Diagnostics | 100 uL, 500 uL | EUR 602.4 |
Human IgM, Myeloma Plasma (isotype control) |
|||
| 20007-2-M | Alpha Diagnostics | 1 mg | EUR 270 |
Human IgA1 (myeloma) purified (isotype control) |
|||
| 20007-6-100 | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human IgA1 (myeloma) purified (isotype control) |
|||
| 20007-6-500 | Alpha Diagnostics | 500 ug | EUR 562.8 |
